Addiction Rehab: A Preliminary Feasibility Study of Varenicline for Smoking Cessation in Bipolar Disorder.
A Preliminary Feasibility Study of Varenicline for Smoking Cessation in Bipolar Disorder.
Filed under: Addiction Rehab
J Dual Diagn. 2012 Apr 1; 8(2): 131-132
Wu BS, Weinberger AH, Mancuso E, Wing VC, Haji-Khamneh B, Levinson AJ, George TP
Children, Technology, Problems, and Preferences.
Filed under: Addiction Rehab
J Clin Psychol. 2012 Sep 7;
Farber BA, Shafron G, Hamadani J, Wald E, Nitzburg G
Increasingly, young people are using various forms of technology in the service of communicating with others, and many have noted the possibility of various dire consequences of this phenomenon, including sexting, cyberbullying, online harassment, and Internet addiction. In our own survey of over 300 adolescents, we found that texting and face-to-face communication were considered the most “convenient” forms of communication, while face-to-face communication and phone conversations were perceived as most likely to lead to “feeling understood” and “feeling intimate.” Face-to-face communication and texting were perceived as most likely to result in feeling regret for sharing too much information. By choosing to communicate through technology, many young people, including our patients, can continue to be social and, at the same time, keep a somewhat safer emotional distance.
HubMed – addiction
Introduction: Clinicians Respond to Their Clients’ Technology.
Filed under: Addiction Rehab
J Clin Psychol. 2012 Sep 7;
Rosegrant J
The contributors to this special issue of The Journal of Clinical Psychology: In Session have given us a wide range of ideas about technology use among children and adolescents, illustrated with rich clinical material. Of the many interesting issues they raise, I briefly discuss four that are particularly salient: the interaction of technology with personality and development; the concept of Internet addiction; the importance of adult guidance and limit setting; and technology and clinical creativity. Taken as a whole, these papers suggest that while technology can certainly contribute to and help create pathology, it can also contribute to growth, and that in either case technology interacts with fundamental human needs and developmental processes.
HubMed – addiction
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.
Filed under: Addiction Rehab
Nat Struct Mol Biol. 2012 Sep 9;
Khare T, Pai S, Koncevicius K, Pal M, Kriukiene E, Liutkeviciute Z, Irimia M, Jia P, Ptak C, Xia M, Tice R, Tochigi M, Moréra S, Nazarians A, Belsham D, Wong AH, Blencowe BJ, Wang SC, Kapranov P, Kustra R, Labrie V, Klimasauskas S, Petronis A
The 5-methylcytosine (5-mC) derivative 5-hydroxymethylcytosine (5-hmC) is abundant in the brain for unknown reasons. Here we characterize the genomic distribution of 5-hmC and 5-mC in human and mouse tissues. We assayed 5-hmC by using glucosylation coupled with restriction-enzyme digestion and microarray analysis. We detected 5-hmC enrichment in genes with synapse-related functions in both human and mouse brain. We also identified substantial tissue-specific differential distributions of these DNA modifications at the exon-intron boundary in human and mouse. This boundary change was mainly due to 5-hmC in the brain but due to 5-mC in non-neural contexts. This pattern was replicated in multiple independent data sets and with single-molecule sequencing. Moreover, in human frontal cortex, constitutive exons contained higher levels of 5-hmC relative to alternatively spliced exons. Our study suggests a new role for 5-hmC in RNA splicing and synaptic function in the brain.
HubMed – addiction
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