Drug and Alcohol Rehabilitation: MicroRNAs as Newer Therapeutic Targets: A Big Hope From a Tiny Player.
MicroRNAs as newer therapeutic targets: A big hope from a tiny player.
Filed under: Drug and Alcohol Rehabilitation
J Pharmacol Pharmacother. 2012 Jul; 3(3): 217-27
Ghelani HS, Rachchh MA, Gokani RH
MicroRNAs (miRNAs) are a novel group of universally present small noncoding endogenous RNAs that regulate gene expression and protein coding by base pairing with the 3′ untranslated region (UTR) of target mRNAs. So they have been associated with several physiological processes and play an important role in the manifestation of diverse diseases. miRNAs expression is associated with the normal and diverse pathophysiological state including cardiac hypertrophy, neurodegenerative diseases, diabetes and its complication, and cancer because individual miRNAs are associated with the regulation of the expression of multiple target genes. Modulating the expression of a single miRNA can influence an entire gene network and thereby modify complex disease phenotypes. From recent studies, it has been confirmed that miRNA has a potential physiological role in various body systems. But in some specialized condition over expression of miRNA within the cytoplasm also leads to some pathological condition in the body. Here, we summarize the roles of miRNAs in various pathological conditions and consider the advantages and potential challenges of miRNA-based therapeutic approaches compared to conventional drug-based therapies.
HubMed – drug
Additional thoughts on drug shortages.
Filed under: Drug and Alcohol Rehabilitation
Can J Hosp Pharm. 2012 Sep; 65(5): 407-8
Chan J
Drug shortages: what does france do better than Canada?
Filed under: Drug and Alcohol Rehabilitation
Can J Hosp Pharm. 2012 Sep; 65(5): 406-7
Barthélémy I, Bussières JF, Lebel D, Gaudreault P, Prot-Labarthe S, Bourdon O
St. Anthony’s Farm – A 6 month drug and alcohol rehabilitation program out of San Fransisco, California. Farming and hope grown here. Host: Tracy Sellers. A segment from California Country.
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