Treatment of Hypertrophic Osteoarthropathy in the Case of Pulmonary Metastasis Secondary-to-Nasopharyngeal Carcinoma With Zoledronic Acid: An Enlightening Experience.

Treatment of hypertrophic osteoarthropathy in the case of pulmonary metastasis secondary-to-nasopharyngeal carcinoma with zoledronic acid: an enlightening experience.

Filed under: Drug and Alcohol Rehabilitation

BMJ Case Rep. 2012; 2012:
Sonthalia N, Mukherjee K, Saha A, Talukdar A

We describe a case of 23-year-old man, who presented with painful hypertrophic pulmonary osteoarthropathy involving bilateral upper and lower extremities, resulting from intrathoracic metastasis. The patient had a history of undifferentiated nasopharyngeal carcinoma which was treated successfully 2 years ago. The painful osteoarthropathy had made the patient incapacitated. A single dose of 4 mg of intravenous zoledronic acid (ZA) was given which resulted in complete resolution of pain along with reduction of swelling. There was no recurrence on follow-up. Bisphosphonates by their action on bone metabolism might alleviate the symptoms and its use should be encouraged in cancer patients with debilitating arthropathies. This article aims at highlighting the role of bisphosphonates, particularly ZA in managing patients with hypertrophic osteoarthropathy (HOA) and sharing our experience with this drug because of the rarity of the condition and lack of sufficient data in the medical literature.
HubMed – drug

 

A megafund for drug development.

Filed under: Drug and Alcohol Rehabilitation

Cancer Discov. 2012 Nov; 2(11): OF6

A proposed megafund would combine debt securities with equity investments to help pay for high-risk biomedical research.
HubMed – drug

 

Cancer drugs cross finish line faster in u.s.

Filed under: Drug and Alcohol Rehabilitation

Cancer Discov. 2012 Nov; 2(11): OF1

An analysis of drug approval times over the past decade shows that oncologic agents make it to market faster in the United States than non-oncologic drugs-and faster than cancer medicines in the European Union.
HubMed – drug

 

Network Analysis of NRAS Activity Defines a Synergistic Drug Strategy.

Filed under: Drug and Alcohol Rehabilitation

Cancer Discov. 2012 Nov; 2(11): 973

NRAS-driven biologic outputs are gated and can be blocked by combined MEK and CDK4 inhibition.
HubMed – drug

 

 

EC2008 – Fr Chris Riley AM – Hope Through Church Agencies – Father Chris Riley AM, who spoke at our Eucharistic Convention in 2008, has just been named NSW Australian of the Year 2012 Twenty years ago, Father Chris Riley founded Youth Off The Streets (YOTS) with a single food van delivering meals to young homeless people in Kings Cross. Today it is a major agency assisting young people aged 12 to 21 who are homeless, face drug and alcohol dependency, exclusion from school, neglect and abuse. Chris estimates the organisation has helped over 50000 young people with accommodation, education, psychological services and drug and alcohol rehabilitation. And it is his determination, unstinting hard work and respect for both the clients and his 250 staff, that has guaranteed the success and effectiveness of YOTS. Chris believes there is no such thing as ‘a child born bad’ but that they become vulnerable in unsafe environments and circumstances. But with intervention and education, lives can be turned around. In 1997 he opened Key College, an independent high school pioneering a flexible education model to help young homeless people return to school. YOTS now operates Key College on three separate campuses with a fourth school in the Southern Highlands. Twice the winner of the Prime Minister’s Award for Excellence, and the winner of the Human Rights Medal. Chris continues to help disadvantaged Australians with selfless dedication, respect and good humour. In this video Father Chris talks about his work as a Catholic priest in helping those …

 

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