The Chinese Version of the Addiction Severity Index (ASI-C): Reliability, Validity, and Responsiveness in Chinese Patients With Alcohol Dependence.

The Chinese version of the Addiction Severity Index (ASI-C): Reliability, validity, and responsiveness in Chinese patients with alcohol dependence.

Filed under: Addiction Rehab

Alcohol. 2012 Dec; 46(8): 777-81
Sun Z, Chen H, Su Z, Zhou X, Zhang S, Hao W, Zhang R

We evaluated the reliability, validity, and responsiveness of the Chinese version of the 5th edition Addiction Severity Index (ASI-C-5) in Chinese male alcohol-dependent inpatients. Three hundred and fifty-four inpatients with alcohol dependence from five regions of China were interviewed in person by five trained interviewers using the ASI-C-5. Responses were then analyzed for internal consistency reliability, discriminant validity, criterion validity, and responsiveness. Forty subjects were re-interviewed 7 days later to assess test-retest reliability. The ASI-C-5 had good internal consistency, with an overall standardized Cronbach’s alpha of 0.79. The Cronbach’s alpha values for internal consistency of domain CSs ranged from 0.48 to 0.95, and were above 0.60 for six domains. The 7 day test-retest reliability was acceptable as evidenced by high Pearson correlation coefficients (0.75-0.92, p < 0.01) for 6 of 7 domain CSs. Correlation coefficients between the seven domain CSs ranged from 0.007 to 0.390 (p < 0.05 or 0.01 two-sided), indicating strong discriminant validity. The correlation coefficient between the alcohol dependence composite score of ASI-C-5 and the Alcohol Use Disorders Identification Test (AUDIT) was 0.69 (p < 0.01), indicating good criterion validity. The frequency of extreme scores was low, except for significant floor effects in the "Drugs" and "Legal Status" domains. Collectively, these findings suggest that the ASI-C-5 exhibited strong reliability, validity, and responsiveness in Chinese male alcohol-dependent inpatients. HubMed – addiction

5-HTTLPR genotype and daily negative mood moderate the effects of sertraline on drinking intensity.

Filed under: Addiction Rehab

Addict Biol. 2012 Nov 12;
Kranzler HR, Armeli S, Tennen H, Covault J

We previously reported moderating effects of age of onset of alcohol dependence (AD) and a functional polymorphism (5-HTTLPR) in the gene encoding the serotonin transporter protein in a sample of 134 individuals participating in a 12-week, placebo-controlled trial of sertraline. To understand more fully the effects seen in that study, we examined moderation by negative moods reported each evening, with nighttime drinking intensity (i.e. the number of standard drinks consumed at night) as the dependent variable. We found a daily anxiety?×?age of onset?×?5-HTTLPR polymorphism?×?medication interaction, which reflected a daily anxiety?×?medication group effect for early-onset individuals homozygous for the high-expression (L’) allele, but not others. Specifically, on days characterized by relatively high levels of anxiety, early-onset L’ homozygotes receiving placebo reduced their drinking intensity significantly. In contrast, early-onset L’ homozygotes treated with sertraline non-significantly increased their drinking intensity. These findings implicate anxiety as a key moderator of the observed pharmacogenetic effects. These findings have important implications because of the high prevalence of AD and the frequency with which SSRIs are prescribed to treat the disorders.
HubMed – addiction

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