Drug and Alcohol Rehabilitation: Genetic Variations in Drug-Induced Liver Injury (DILI): Resolving the Puzzle.

Genetic variations in drug-induced liver injury (DILI): resolving the puzzle.

Filed under: Drug and Alcohol Rehabilitation

Front Genet. 2012; 3: 253
Stephens C, Lucena MI, Andrade RJ

HubMed – drug

Current approaches on viral infection: proteomics and functional validations.

Filed under: Drug and Alcohol Rehabilitation

Front Microbiol. 2012; 3: 393
Zheng J, Tan BH, Sugrue R, Tang K

Viruses could manipulate cellular machinery to ensure their continuous survival and thus become parasites of living organisms. Delineation of sophisticated host responses upon virus infection is a challenging task. It lies in identifying the repertoire of host factors actively involved in the viral infectious cycle and characterizing host responses qualitatively and quantitatively during viral pathogenesis. Mass spectrometry based proteomics could be used to efficiently study pathogen-host interactions and virus-hijacked cellular signaling pathways. Moreover, direct host and viral responses upon infection could be further investigated by activity-based functional validation studies. These approaches involve drug inhibition of secretory pathway, immunofluorescence staining, dominant negative mutant of protein target, real-time PCR, small interfering siRNA-mediated knockdown, and molecular cloning studies. In this way, functional validation could gain novel insights into the high-content proteomic dataset in an unbiased and comprehensive way.
HubMed – drug

Does C-reactive protein contribute to atherothrombosis via oxidant-mediated release of pro-thrombotic factors and activation of platelets?

Filed under: Drug and Alcohol Rehabilitation

Front Physiol. 2012; 3: 433
Zhang Z, Yang Y, Hill MA, Wu J

Inflammation and the generation of reactive oxygen species (ROS) have been implicated in the initiation and progression of atherosclerosis. Although C-reactive protein (CRP) has traditionally been considered to be a biomarker of inflammation, recent in vitro and in vivo studies have provided evidence that CRP, itself, exerts pro-thrombotic effects on vascular cells and may thus play a critical role in the development of atherothrombosis. Of particular importance is that CRP interacts with Fc? receptors on cells of the vascular wall giving rise to the release of pro-thrombotic factors. The present review focuses on distinct sources of CRP-mediated ROS generation as well as the pivotal role of ROS in CRP-induced tissue factor expression. These studies provide considerable insight into the role of the oxidative mechanisms in CRP-mediated stimulation of pro-thrombotic factors and activation of platelets. Collectively, the available data provide strong support for ROS playing an important intermediary role in the relationship between CRP and atherothrombosis.
HubMed – drug

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