Circulating Interleukin 6 and Soluble Forms of Its Receptors in Relation to Resting Energy Expenditure in Women With Anorexia Nervosa.

Circulating interleukin 6 and soluble forms of its receptors in relation to resting energy expenditure in women with anorexia nervosa.

Filed under: Eating Disorders

Clin Endocrinol (Oxf). 2012 Dec 1;
Karczewska-Kupczewska M, Adamska A, Niko?ajuk A, Otziomek E, Górska M, Kowalska I, Str?czkowski M

CONTEXT: Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signaling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130, respectively). sIL-6R sensitizes cells towards IL-6, whereas sgp130 inhibits gp130 signaling. OBJECTIVE: To estimate circulating IL-6/sIL-6R/sgp130 system and its relationships with body weight and resting energy expenditure (REE) in AN women. PATIENTS: We examined 19 women with AN and 27 healthy normal weight female controls. MEASUREMENTS: Indirect calorimetry and the measurement of serum IL-6, sIL-6R and sgp130 concentrations were performed in all the subjects. RESULTS: REE was decreased in AN women (p<0.001). Serum IL-6 was higher in AN women in comparison with control group (p=0.005). Serum sIL-6R was lower (p=0.009) and serum sgp130 was higher (p=0.004) in AN women in comparison with controls. IL-6 and sIL-6R were related to REE in the entire study population (r=-0.54, p<0.001 and r=0.48, p=0.001, respectively) and in AN group (r=-0.54, p=0.024 and r=0.60, p=0.011, respectively). CONCLUSIONS: Increased IL-6 in AN seems to be compensated by the changes in sIL-6R and sgp130 which are directed towards inhibition of IL-6 action. The balance between these factors might play a role in the regulation of energy expenditure in AN. © 2012 Blackwell Publishing Ltd. HubMed – eating

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