Rehab Centers: Efficacy and Safety of Biologic Treatments in Familial Mediterranean Fever.
Efficacy and Safety of Biologic Treatments in Familial Mediterranean Fever.
Filed under: Rehab Centers
Am J Med Sci. 2012 Dec 28;
Akgul O, Kilic E, Kilic G, Ozgocmen S
OBJECTIVE:: Colchicine is the mainstay treatment for Familial Mediterranean Fever (FMF). However 5% to 10% of the patients with FMF are unresponsive or intolerant to colchicine. Biologics are efficient in many rheumatic diseases, including rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, cryopyrin-associated periodic syndromes. We performed a systematic review to analyze patients with FMF, including juvenile patients who received treatment with biologics. METHODS:: A MEDLINE search, including articles published in English language between 1990 and May 2012, was performed. Patients who had MEFV variants but could not be classified as FMF according to Tel-Hashomer criteria were excluded. RESULTS:: There is no controlled trial on the efficacy and safety of biologics in FMF. Fifty-nine (32 female and 27 male) patients with FMF who had been treated with biologics (infliximab, etanercept, adalimumab, anakinra, and canakinumab) were reported in 24 single reports and 7 case series. There were 16 children and 43 adults (7- to 68-year olds). Five patients were reported to have colchicine intolerance or had adverse events related to colchicine use, and the rest 54 were unresponsive to colchicine treatment. CONCLUSIONS:: The current data are limited to case reports, and it is difficult to obtain a quantitative evaluation of response to biologic treatments. However, on the basis of reported cases, biologic agents seem to be an alternative treatment for patients with FMF who are unresponsive or intolerant to colchicine therapy and seem to be safe. Controlled studies are needed to better evaluate the safety and efficacy of biologics in the treatment of patients with FMF.
HubMed – rehab
Acute Exacerbations of COPD: Will On-Call Physiotherapy Allow for Early Rehabilitation?
Filed under: Rehab Centers
Chest. 2013 Jan 1; 143(1): 280-1
Babu AS
The BioMotionBot: a robotic device for applications in human motor learning and rehabilitation.
Filed under: Rehab Centers
J Neurosci Methods. 2012 Dec 28;
Bartenbach V, Sander C, Pöschl M, Wilging K, Nelius T, Doll F, Burger W, Stockinger C, Focke A, Stein T
Robotic manipulanda are an established tool for the investigation of human motor control and learning. Potentially, robotic manipulanda could also be valuable in the investigation of skill learning in more natural movement tasks. Most current designs have been developed for studying dynamic learning and rehabilitation and are restricted to 2D space. However, natural upper limb movements take place in 3D space, sometimes with high underlying forces. In this paper, we introduce a robotic device, the BioMotionBot, that can be used in established applications of dynamic learning and rehabilitation but also enables the investigation of skill learning in more natural 3D movement tasks with large dynamic perturbations. The design of the BioMotionBot is based on a mechanism with hybrid serial and parallel kinematics. We first describe the BioMotionBot’s mechanical design, the electronic components, the software structure and the control system. To investigate the performance of the BioMotionBot, its stiffness, endpoint mass, endpoint viscosity, haptic resolution, force depth and impedance ratio are evaluated. Additionally, we develop a detailed multi-body simulation model to validate aspects of the structure and behavior of the BioMotionBot. Finally, we present experimental data from a dynamic learning task in 2D and test a 3D scenario with virtual walls. Our results demonstrate that the BioMotionBot can be used for research in human motor learning and rehabilitation and also has potential for the investigation of skill learning in more natural 3D movement tasks.
HubMed – rehab
The disabled throwing shoulder: spectrum of pathology-10-year update.
Filed under: Rehab Centers
Arthroscopy. 2013 Jan; 29(1): 141-161.e26
Kibler WB, Kuhn JE, Wilk K, Sciascia A, Moore S, Laudner K, Ellenbecker T, Thigpen C, Uhl T
In the 10 years since the current concept series entitled “The Disabled Throwing Shoulder: Spectrum of Pathology” was conceived and written, many studies have been reported that add much more information to the understanding of the disabled throwing shoulder (DTS). The editors of Arthroscopy and the authors of the original series believed that an update to the original series would be beneficial to provide an organized overview of current knowledge that could update the thought process regarding this problem, provide better assessment and treatment guidelines, and guide further research. A dedicated meeting, including current published researchers and experienced clinicians in this subject, was organized by the Shoulder Center of Kentucky. The meeting was organized around 5 areas of the DTS that were highlighted in the original series and appear to be key in creating the DTS spectrum and to understanding and treating the DTS: (1) the role of the kinetic chain; (2) the role and clinical evaluation of the scapula; (3) the role of deficits in glenohumeral rotation, glenohumeral internal rotation deficit, and total range-of-motion deficit in the causation of labral injury and DTS; (4) the role of superior labral (SLAP) injuries and rotator cuff injuries; and (5) the composition and progression of rehabilitation protocols for functional restoration of the DTS. The meeting consisted of presentations within each area, followed by discussions, and resulted in summaries regarding what is known in each area, what is not known but thought to be important, and strategies to implement and enlarge the knowledge base.
HubMed – rehab
US Physical Therapy: Lori Frymire, Partner, I get the help I need from USPH – US Physical Therapy: Lori Frymire, Partner, I get the help I need from USPH
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