Addiction Rehab: mGlu(5) Negative Allosteric Modulators: A Patent Review (2010 – 2012).

mGlu(5) negative allosteric modulators: a patent review (2010 – 2012).

Filed under: Addiction Rehab

Expert Opin Ther Pat. 2013 Jan 22;
Emmitte KA

Introduction: The design and development of small molecule negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu(5)) has been an area of intense interest for over a decade. Potential roles have been established for mGlu(5) NAMs in the treatment of diseases such as pain, anxiety, gastroesophageal reflux disease (GERD), Parkinson’s disease levodopa-induced dyskinesia (PD-LID), fragile X syndrome (FXS), autism, addiction, and depression. Areas covered: This review begins with an update of the clinical trial efforts with mGlu(5) NAMs. Following that update, the review summarizes small molecule mGlu(5) NAM patent applications published between 2010 and 2012. These summaries are subdivided into three separate groups: inventions related to improvements in drug properties and/or developability, new chemical entities that contain a disubstituted alkyne, and new chemical entities that do not contain a disubstituted alkyne. Expert opinion: Given the abundant promise found within the mGlu(5) NAM field, optimism remains that a drug will emerge from this therapeutic class. Still, the launch of a new drug is far from a certainty. It is encouraging to observe the ever-increasing chemical diversity among mGlu(5) NAMs. Finally, in spite of the mature nature of this field, room remains for new advancements.
HubMed – addiction

MYC ADDICTION IN CHRONIC LYMPHOCYTIC LEUKEMIA.

Filed under: Addiction Rehab

Leuk Lymphoma. 2013 Jan 23;
Rossi D

HubMed – addiction

Long Term Drug Treatment and Long Term Drug Rehab in Florida – The Gonzalez Recovery Residences (The GRR) provide a series of drug addiction treatment services including affordable and appealing long term drug treatment. The GRR addiction recovery programs include effective home style living facilities that are comparable or better than those at the best alcohol treatment centers and drug treatment centers. The GRR are some of the top addiction rehab facilities in Florida and in Virginia today. The GRR has personalized extended after care programs for substance abuse and/or chemical dependency coupled with affordable and effective long term addiction treatment. The continuing care structured addiction treatment environments are extremely diverse: they run the gamut from the very economical to the very high end, customized, executive retreat end of the spectrum. In any case the discernable quality for the price is palpable. A variety of attractive, comfortable, affordable residential, structured sober living homes are available. Each individual is offered practical, supportive tools that are designed to promote the skills required for a gradual re-integration into the “real world”. Relapse prevention and life coaching, mixed with an enjoyable environment make The GRR the best choice for a Florida rehabilitation experience. The GRR is an ideal choice for those seeking a dignified approach to long term extended care rehab programs and appealing long term drug rehab with proven results. In the words of Father Joseph C. Martin the Co …

Related Addiction Rehab Information…