Periodontal Regeneration Following Application of Basic Fibroblast Growth Factor-2 in Combination With Beta Tricalcium Phosphate in Class III Furcation Defects in Dogs.

Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs.

Dent Mater J. 2013; 32(2): 256-62
Saito A, Saito E, Kuboki Y, Kimura M, Nakajima T, Yuge F, Kato T, Honma Y, Takahashi T, Ohata N

The aim of this study was to investigate the effect of tunnel structured ?-tricalcium phosphate (?-TCP) on the regenerative potential of basic fibroblast growth factor-2 (bFGF-2) in class III furcation defects in dogs. The furcations of 30 mandibular premolar teeth received: 1) 0.3% bFGF-2 solution in conjunction with ?-TCP; 2) 0.3% bFGF-2 solution; and 3) no implant material (Control group). The dogs were sacrificed 8 weeks post-surgery, and healing was evaluated histologically. New bone formation was significantly greater in the bFGF-2/?-TCP group compared to the bFGF-2 solution and Control groups (p<0.01). New cementum formation in the bFGF-2/?-TCP and bFGF-2 solution groups was significantly greater than that in the Control group (p<0.01). These findings suggested that bFGF-2 alone enhances connective tissue attachment in a manner similar to the combination of bFGF-2 and ?-TCP. Furthermore, this combination enhances bone formation up to the fornix in class III furcation defects. HubMed – rehab

Mapping patient goals to the International Classification of Functioning, Disability and Health (ICF): Examining the content validity of the low back pain core sets.

J Rehabil Med. 2013 Mar 27;
Bagraith KS, Hayes J, Strong J

Objective: To determine whether the International Classification of Functioning, Disability and Health (ICF) Low Back Pain Core Sets are sufficient to cover the activity and participation goals that patients prioritize when commencing multidisciplinary rehabilitation. Design: Prospective multi-site cross-sectional questionnaire study. Subjects: Patients with chronic low back pain attending multidisciplinary outpatient clinics at two metropolitan hospitals in Australia. Methods: Participants used the Patient Specific Functional Scale to record goals when commencing rehabilitation. Two raters employed a standardized procedure to extract and link goal concepts to the ICF. A description exploration was undertaken with reference to the low back pain Core Sets. Sample size was determined via saturation. Results: Saturation was achieved with 33 participants. Ninetyfive goals were identified, from which 109 concepts were extracted. All of the concepts could be linked to the ICF, spanning 23 2nd-level categories. The comprehensive and brief core sets encompassed 95% and 65% of the concepts respectively. Maintaining body position (d415), doing housework (d640), changing basic body position (d410) and walking (d450) accounted for the majority (50.5%) of goals. Conclusion: This study confirms the content validity of the low back pain Core Sets from the patients’ perspective. The Core Sets are likely to have good clinical utility, however, additional research is required to substantiate whether ratings of ICF based goals can be used to measure goal achievement. HubMed – rehab

Dry Eye in Patients With Fibromyalgia and Its Relevance to Functional and Emotional Status.

Cornea. 2013 Mar 27;
Türkyilmaz K, Türkyilmaz AK, Kurt EE, Kurt A, Oner V

PURPOSE:: To evaluate dry eye in patients with fibromyalgia (FM). METHODS:: Fifty-three FM patients and 53 age and sex well-matched controls were included in this study. Visual analog scale (VAS), number of tender points, FM impact questionnaire (FIQ), Beck depression scale (BDS), Ocular Surface Disease Index (OSDI), the tear break-up time (TBUT), Schirmer test, and tear osmolarity (TO) were assessed. RESULTS:: The OSDI, TBUT, Schirmer test, and TO scores of the FM and control groups were significantly different (P < 0.05). The OSDI, TBUT, Schirmer test, and TO were higher in FM with high FIQ, and TBUT and TO were higher in FM with high BDS. In FM patients, Schirmer test was correlated with the VAS (r = -0.429, P = 0.001), BDS (r = -0.277, P = 0.044), and FIQ (r = -0.382, P = 0.005), and the TBUT was correlated with the VAS (r = -0.537, P < 0.001), BDS (r = -0.350, P = 0.010), and FIQ (r = -0.456, P = 0.001). In addition, TO was significantly correlated with the VAS (r = 0.681, P < 0.001), BDS (r = 0.661, P < 0.001), and FIQ (r = 0.842, P < 0.001). However, no significant correlation existed between the OSDI and the VAS, BDS, or FIQ. CONCLUSIONS:: We have revealed an association between FM disease activity and dry eye severity. The consideration of this relation will be useful in the treatment of FM with deteriorated clinical status. HubMed – rehab