A Greater Number of Somatic Pain Sites Is Associated With Poor Mental Health in Adolescents: A Cross-Sectional Study.
A greater number of somatic pain sites is associated with poor mental health in adolescents: a cross-sectional study.
Filed under: Depression Treatment
BMC Psychiatry. 2013 Jan 17; 13(1): 30
Ando S, Yamasaki S, Shimodera S, Sasaki T, Oshima N, Furukawa TA, Asukai N, Kasai K, Mino Y, Inoue S, Okazaki Y, Nishida A
ABSTRACT: BACKGROUND: Identifying indicators of poor mental health during adolescence is a significant public health issue. Previous studies which suggested an association between the number of somatic pains and depression have mainly focused on adults or have employed samples with a narrow age range. To date, results from previous studies have been inconsistent regarding the association between somatic pain and academic impairment. Therefore, the main aims of the present study were to 1) investigate the association between the number of somatic pain sites and poor mental health using a community sample of adolescents aged 12 to 18 years and employing a simple method of assessment, and 2) examine the association between the number of somatic pain sites and perceived academic impairment. METHODS: Data analysis was conducted using a large cross-sectional survey of adolescents in grades 7 to 12. The one-month prevalence rates for three sites of somatic pain including head, neck and shoulders, and abdomen were examined. Poor mental health was evaluated using the General Health Questionnaire, and perceived academic impairment was measured using a self-report questionnaire. RESULTS: A total of 18,104 adolescents participated in the survey. A greater number of pain sites was associated with poor mental health, and this association was consistent across age and gender. There was no difference in effect on mental health between any of the pain sites. Although there was an association between the number of somatic pain sites and perceived academic impairment, the results suggested that the association was mediated by poor mental health. CONCLUSIONS: Simple reporting methods for assessing the number of pain sites may be a feasible indicator of poor mental health in adolescents. Professionals working with adolescents should consider the possibility of poor mental health, especially when students report multiple somatic pains.
HubMed – depression
Progress in targeting tumor cells by using drug-magnetic nanoparticles conjugate.
Filed under: Depression Treatment
Biomacromolecules. 2013 Jan 17;
Nowicka AM, Kowalczyk A, Jarzebinska A, Donten M, Krysinski PG, Stojek ZJ, Augustin E, Mazerska Z
To limit cytotoxicity of anticancer drugs against healthy cells an appropriate carrier should be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a magnetic nanoparticle to the molecule of the drug and to use a properly directed external magnetic field. The modified by us synthesis of the conjugate of doxorubicin with magnetic nanoparticles (iron oxide) resulted in a substantial depression of the aggregation process of the nanoparticles and therefore allowed the correct examination of cytotoxicity of the modified drug. It has been shown, by performing the electrochemical microbalance measurements, that the use of magnetic field guaranteed the efficient delivery of the drug to the desired place. The change in the synthesis procedure led to an increase in the number of DOX molecules attached to one magnetic nanoparticle. The release of the drug took place at pH 5.8 (and below it), which pH characterizes the cancer cells. It has also been found that while the iron oxide magnetic nanoparticles were not cytotoxic toward human urinary bladder carcinoma cells UM-UC-3, the tumor cell sensitivity of the DOX-Np complex was slightly higher in comparison to the identical concentration of doxorubicin alone.
HubMed – depression
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