Adrenocortical Carcinoma: Current Therapeutic State-of-the-Art.
Adrenocortical Carcinoma: Current Therapeutic State-of-the-Art.
Filed under: Drug and Alcohol Rehabilitation
J Oncol. 2012; 2012: 234726
Lebastchi AH, Kunstman JW, Carling T
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy that generally conveys a poor prognosis. Currently, surgical resection is considered the lone curative treatment modality. In addition, the low prevalence of ACC has limited effective clinical trial design to develop evidence-based approaches to ACC therapy. The proper role of radio- and chemotherapy treatment for ACC is still being defined. Similarly, the molecular pathogenesis of ACC remains to be fully characterized. Despite these challenges, progress has been made in several areas. After years of refinement, an internationally accepted staging system has been defined. International collaborations have facilitated increasingly robust clinical trials, especially regarding agent choice and patient selection for chemotherapeutics. Genetic array data and molecular profiling have identified new potential targets for rational drug design as well as potential tumor markers and predictors of therapeutic response. However, these advances have not yet been translated into a large outcomes benefit for ACC patients. In this paper, we summarize established therapy for ACC and highlight recent findings in the field that are impacting clinical practice.
HubMed – drug
Ocular drug delivery: a clue from nanotechnology.
Filed under: Drug and Alcohol Rehabilitation
Front Pharmacol. 2012; 3: 188
Bucolo C, Drago F, Salomone S
Potential drug mechanism(s) targeting the contractile status of hepatic stellate cells.
Filed under: Drug and Alcohol Rehabilitation
Front Pharmacol. 2012; 3: 187
Bucolo C, Drago F, Salomone S
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