Benchmarking Human Protein Complexes to Investigate Drug-Related Systems and Evaluate Predicted Protein Complexes.
Benchmarking human protein complexes to investigate drug-related systems and evaluate predicted protein complexes.
Filed under: Drug and Alcohol Rehabilitation
PLoS One. 2013; 8(2): e53197
Wu M, Yu Q, Li X, Zheng J, Huang JF, Kwoh CK
Protein complexes are key entities to perform cellular functions. Human diseases are also revealed to associate with some specific human protein complexes. In fact, human protein complexes are widely used for protein function annotation, inference of human protein interactome, disease gene prediction, and so on. Therefore, it is highly desired to build an up-to-date catalogue of human complexes to support the research in these applications. Protein complexes from different databases are as expected to be highly redundant. In this paper, we designed a set of concise operations to compile these redundant human complexes and built a comprehensive catalogue called CHPC2012 (Catalogue of Human Protein Complexes). CHPC2012 achieves a higher coverage for proteins and protein complexes than those individual databases. It is also verified to be a set of complexes with high quality as its co-complex protein associations have a high overlap with protein-protein interactions (PPI) in various existing PPI databases. We demonstrated two distinct applications of CHPC2012, that is, investigating the relationship between protein complexes and drug-related systems and evaluating the quality of predicted protein complexes. In particular, CHPC2012 provides more insights into drug development. For instance, proteins involved in multiple complexes (the overlapping proteins) are potential drug targets; the drug-complex network is utilized to investigate multi-target drugs and drug-drug interactions; and the disease-specific complex-drug networks will provide new clues for drug repositioning. With this up-to-date reference set of human protein complexes, we believe that the CHPC2012 catalogue is able to enhance the studies for protein interactions, protein functions, human diseases, drugs, and related fields of research. CHPC2012 complexes can be downloaded from http://www1.i2r.a-star.edu.sg/xlli/CHPC2012/CHPC2012.htm.
HubMed – drug
Morphology Controlled Porous Calcium Phosphate Nanoplates and Nanorods with Enhanced Protein Loading and Release Functionality.
Filed under: Drug and Alcohol Rehabilitation
Adv Healthc Mater. 2013 Feb 13;
Reardon PJ, Huang J, Tang J
Calcium phosphate nanoplates and nanorods with controllable pores and enhanced protein loading and tuneable release characteristics are first synthesized without the use of any toxic surfactants by an energy efficient microwave assisted chemical process, hence demonstrating their viability as a tool for controllable drug delivery in biomaterial systems.
HubMed – drug
Bifurcation stenting after failed angioplasty of infrapopliteal arteries in critical limb ischemia: Techniques and short-term follow-up.
Filed under: Drug and Alcohol Rehabilitation
Catheter Cardiovasc Interv. 2013 Feb 13;
Werner M, Scheinert S, Bausback Y, Bräunlich S, Ulrich M, Piorkowski M, Scheinert D, Schmidt A
OBJECTIVES: To report on the efficacy of drug eluting stents (DES) in below the knee lesions involving arterial bifurcations after failed angioplasty. BACKGROUND: DES have become a mainstay in the treatment of below the knee lesions. However, little is known about the efficacy of DES in infapopliteal lesions involving the arterial bifurcations. This is the first report on the endovascular treatment of below-the knee bifurcations. METHODS: 11 patients with critical lower limb ischemia (CLI) and complex infrapopliteal atherosclerotic disease underwent provisional DES placement in infrapopliteal bifurcation lesions. Clinical and angiographic follow-up data were prospectively collected in all patients. RESULTS: Technical success was achieved in all cases. After 6 months, the two vessel primary patency (2VPP) rate was 54.5% and the one vessel primary patency (1VPP) rate was 81.8%. Between baseline and the follow-up, mean ABI increased from 0.31±0.10 to 0.68±0.16, and mean Rutherford-Becker class (RBC) decreased from 4.73±0.20 to 3.00±1.41 (p<0.001 for both comparisons). CONCLUSIONS: Bifurcation stenting techniques, that are described for the coronary arteries can be also performed in the infrapopliteal arteries. However, early reocclusion was frequent in this case series, when stenting was performed in a bail-out setting. If balloon angioplasty alone leads to no sufficient results in bifurcation lesions, a single stent strategy could also be considered. © 2013 Wiley Periodicals, Inc. HubMed – drug
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