Crucial Factors and Emerging Concepts in Ultrasound-Triggered Drug Delivery.
Crucial factors and emerging concepts in ultrasound-triggered drug delivery.
Filed under: Drug and Alcohol Rehabilitation
J Control Release. 2012 Dec 28; 164(3): 248-55
Geers B, Dewitte H, De Smedt SC, Lentacker I
Time and space controlled drug delivery still remains a huge challenge in medicine. A novel approach that could offer a solution is ultrasound guided drug delivery. “Ultrasonic drug delivery” is often based on the use of small gas bubbles (so-called microbubbles) that oscillate and cavitate upon exposure to ultrasound waves. Some microbubbles are FDA approved contrast agents for ultrasound imaging and are nowadays widely investigated as promising drug carriers. Indeed, it has been observed that upon exposure to ultrasound waves, microbubbles may (a) release the encapsulated drugs and (b) simultaneously change the structure of the cell membranes in contact with the microbubbles which may facilitate drug entrance into cells. This review aims to highlight (a) major factors known so far which affect ultrasonic drug delivery (like the structure of the microbubbles, acoustic settings, etc.) and (b) summarizes the recent preclinical progress in this field together with a number of promising new concepts and applications.
HubMed – drug
Mathematical modelling: Forecasting cancer.
Filed under: Drug and Alcohol Rehabilitation
Nature. 2012 Nov 22; 491(7425): S66-7
Gammon K
Modelling: Computing cancer.
Filed under: Drug and Alcohol Rehabilitation
Nature. 2012 Nov 22; 491(7425): S62-3
Savage N
Nanotechnology: Carrying drugs.
Filed under: Drug and Alcohol Rehabilitation
Nature. 2012 Nov 22; 491(7425): S58-60
Bourzac K
Second Chances Foundation – Second Chance Scholarships This program provides transitional housing and support for individuals who have completed a drug and alcohol rehabilitation program. Funds would be used for initial two-week residency scholarships for 20 individuals.
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