Cytoskeletal and Extracellular Matrix Alterations in Limb Girdle Muscular Dystrophy 2I Muscle Fibers.
Cytoskeletal and extracellular matrix alterations in limb girdle muscular dystrophy 2I muscle fibers.
Filed under: Rehab Centers
Neurol India. 2012 Sep-Oct; 60(5): 510-1
Sabatelli P, Pellegrini C, Faldini C, Merlini L
In this detailed muscle biopsy study of a patient with molecularly confirmed diagnosis of limb-girdle muscular dystrophy 2I (LGMD2I) we show some new data, that is the presence of altered expression pattern of costamere components as integrin ?7B and integrin ?1D associated with vinculin costameric derangement and basal lamina ultrastructural abnormalities as detachments and discontinuities suggesting that different cellular compartments are involved in LGMD2I and the altered basement membrane-plasmalemma-cytoskeleton binding can underlie muscle degeneration.
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Prevalence of Impaired Glucose Tolerance among Children and Adolescents with Obesity.
Filed under: Rehab Centers
Mymensingh Med J. 2012 Oct; 21(4): 684-90
Mohsin F, Mahbuba S, Begum T, Azad K, Nahar N
The study was undertaken to see the prevalence of impaired glucose tolerance among children and adolescents with obesity, attending the Paediatric Endocrine OPD, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorders (BIRDEM), Dhaka, Bangladesh. A cross sectional study from January 2006 to December 2008 was conducted among obese children and adolescents (6-18 years). Children with any other endocrine disorder, dysmorphism/syndrome were excluded. Obesity was defined as BMI?95th percentile for age and sex using CDC growth chart. Children underwent two hours oral glucose tolerance test with 1.75gm/kg or 75gm of glucose, anthropometric and blood pressure measurement. Fasting serum insulin and lipid profile were measured. Impaired glucose tolerance (IGT) was defined as fasting plasma glucose (FPG) <7mmol/L and 2 hours post glucose load ?7.8mmol/L to <11.1mmol/L. Diabetes mellitus (DM) was defined as FPG ?7mmol/L or 2 hours post glucose load?11.1mmol/L. Homeostasis model assessment was used to estimate insulin resistance. A total of 161 children presented with obesity. Male to female ratio was 1.3:1. Mean age was 10.3±2.5 years. Mean BMI was 27.86±4.1kg/m2. IGT was found in16.9% of children and adolescents. In children aged 6-10 years IGT was detected in16.1% and in adolescents aged 11-18 years IGT was detected in 20%. Diabetes mellitus was detected in 2.1% of subjects, all were adolescents. Serum fasting insulin and hip circumference were significantly higher among children and adolescents with IGT compared to that of normal glucose tolerance. The high rate of IGT among obese children and adolescents is of concern. Factors contributing towards obesity needs to be identified and strategies should be planned for prevention and management of this health problem. HubMed – rehab
[Study on the diagnostic value of lung biopsy in hematologic patients with lung infection].
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Zhonghua Xue Ye Xue Za Zhi. 2012 Aug; 33(8): 658-9
Yuan XL, Zhu ZM, Zhang Y, Lei PC, Wang Z, Guo JM, Yang J, Zang YZ, Liu ZW, Wang TB, Chen YQ, Ma BG
To evaluate the diagnostic value and safety of percutaneous lung biopsy in hematotologic patients with lung infection.28 cases hematologic patients received CT-guided percutaneous lung biopsy when they developed a fever associated with pulmonary nodules or lumps in CT scan whose clinical diagnosis were unclear during or after chemotherapy. Sample of each lesion were drawn twice. The lung tissue was re-scanned after lung biopsy to check up in order to discover bleeding and pneumothorax. Biopsy tissue was examined by bacteria culture, acid-fast staining and pathology. Pathological examination contained HE staining, acid-fast stain, PAS stain, TB-DNA, methenamine silver and others.28 cases contain 24 males and 4 females. Median age was 40 15 – 77 years old. Blood tests were as follows: 3 cases with HGB > 110 g/L, 9 with HGB 90 – 110 g/L, 12 with HGB 60 – 89 g/L, 4 with HGB < 60 g/L. 8 with WBC > 10×10(9)/L, 6 with WBC (4 – 10)×10(9)/L, 13 with WBC < 4×10(9)/L, 1 with WBC < 2×10(9)/L; 14 with PLT > 100×10(9)/L, 5 with PLT (50 – 100)×10(9)/L, 5 with PLT < 50×10(9)/L, 4 with PLT < 30×10(9)/L. 4 cases had mild extended PT, 3 mild extended APTT, 3 FIB lower than normal. Lung CT scans were as follows: 4 cases with simply lesion in right lung, 4 with simply lesion in left lung, 20 with lesions in bilateral lung. 8 cases were diagnosed as fungal infection, 3 as tuberculosis infection, 1 as lung cancer, 1 as pulmonary infiltration of lymphoma, 1 as pulmonary infiltration of leukemia, and 14 as inflammatory changes with no specific diagnosis. 4 cases came with pneumothorax during lung biopsy, mild to moderate in 3 cases and severe in 1 case. Severe patient turned better after CT-guided suction. 3 cases with mild hemoptysis turned better after treatment.When hematopathy patients are with pulmonary nodules or lumps in CT scan whose clinical diagnosis is unclear, CT-guided percutaneous lung biopsy is safe and conducive to early diagnosis and conducive to early rehabilitation of patients if the coagulation function is basically normal and platelet countis not too low. HubMed – rehab
[Hip fracture in patients with dementia: surgery is not always the best alternative].
Filed under: Rehab Centers
Ned Tijdschr Geneeskd. 2012; 156(45): A5237
Meijer-Schafrat EC, Janssens JF, van Delden JJ, Achterberg WP
Patients with dementia are at risk of hip fracture. The prognosis of rehabilitation after surgery is less favourable than in the general population, because of higher mortality, more complications and a longer rehabilitation period. We present 2 female patients with dementia (77 and 86 years old) who each received a different therapy: one surgical, the other conservative. Dutch elderly care physicians make use of advance care planning to determine how to make medical decisions. The policy for treatment might be curative, palliative or symptomatic. When making a medical decision, it is important to consider if a treatment is effective, proportional and if the intended outcome is desirable. In some cases of hip fracture in patients with dementia, conservative treatment and withholding surgery can be good care. More investigation is needed for further evidence-based decision-making.
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