Depression Treatment: Cholinergic Receptor Exocytosis Under Conditions of Depression of Acetylcholine-Induced Current in Edible Snail Neurons in Cellular Analogue of Habituation.
Cholinergic Receptor Exocytosis under Conditions of Depression of Acetylcholine-Induced Current in Edible Snail Neurons in Cellular Analogue of Habituation.
Filed under: Depression Treatment
Bull Exp Biol Med. 2012 Aug; 153(4): 424-7
Makhnovskiy DA, Murzina GB, Pivovarov AS
Exocytosis inhibitor Exo 1 potentiates depression of acetylcholine-induced inward current in defensive behavior command neurons of edible snail, when acetylcholine is applied rhythmically to the soma in cellular correlate of habituation. A mathematical model presupposing different receptor localization in the cell and regularities of their translocations made it possible to analyze the dependence of acetylcholine-induced current depression on a number of intracellular processes. It was concluded that depression of choline-sensitive extrasynaptic zones on the membrane of defensive behavior command neurons in edible snail in cellular correlate of habituation is partially determined by attenuation of exocytosis of internalized cholinergic receptors.
HubMed – depression
The Predictive Value of ??ST/?HR Index for Restenosis after Percutaneous Coronary Intervention.
Filed under: Depression Treatment
Ann Rehabil Med. 2012 Aug; 36(4): 544-50
Kim C, Choi HE
To find out the predictive value of the ??ST/?HR index for restenosis after percutaneous coronary intervention (PCI).Subjects of this research were patients who participated in a cardiac rehabilitation (CR) program as six to eight weeks of a hospital-based program after receiving PCI to treat acute coronary syndrome (ACS). The patients received coronary angiography (CAG) at the onset of the ACS and nine months after that, and also received an exercise tolerance test (ETT) at the start of the CR program and several days before receiving a follow-up CAG. In ETT, we used the sum of the ST depression (??ST index) of leads II, III, aVF, V(4-6) as well as the sum of the ?ST/?HR (heart rate) (??ST/?HR index) in the same leads and the sum of the ?ST/?RPP (rate pressure product) (??ST/?RPP index) in the same leads. We compared the predictive power of each index of ETT for restenosis after PCI.The sensitivity, specificity, positive predictive value, and negative predictive value of ??ST index were 69%, 47%, 31%, and 82%. The ??ST/?HR index was 13.7±5.2 in the restenosis group and 9.3±5.6 in the patent group (p=0.017). The sensitivity, specificity, positive predictive value, and negative predictive value of this index were 85%, 63%, 44%, and 92%. The ??ST/?RPP index were 0.10±0.08 in the restenosis group and 0.06±0.04 in the patent group (p=0.016). The sensitivity, specificity, positive predictive value, and negative predictive value of this index were 54%, 76%, 44%, and 83%.The ??ST/?HR index showed a much higher sensitivity and negative predictive value for restenosis after PCI compared to the ??ST index.
HubMed – depression
Depressive symptoms and childhood sleep apnea syndrome.
Filed under: Depression Treatment
Neuropsychiatr Dis Treat. 2012; 8: 369-73
Carotenuto M, Esposito M, Parisi L, Gallai B, Marotta R, Pascotto A, Roccella M
The relationship between sleep and mood regulation is well known, and some reports suggest a key role of sleep-related breathing disorders (SRBD) in the development of the symptomatology of depression, even if no conclusive data are actually found in the clinical literature. The aim of this study was to assess the relationship between SRBD and depressive symptoms in a population of school-aged children.The study population comprised 94 children affected by SRBD and 107 healthy children. To identify the severity of SRBD, an overnight respiratory evaluation was performed. All subjects filled out the Italian version of the Children Depression Inventory (CDI) to screen for the presence of depressive symptoms.The group with SRBD showed higher CDI scores than the group without SRBD, with a positive correlation found between CDI scores, apnea-hypopnea index, and oxygen desaturation index values. Logistic regression showed that an apnea-hypopnea index ? 3 and an oxygen desaturation index ? 1 could be risk factors for development of depressive symptoms. According to receiver-operating characteristic curve analysis, the cutoff point for the apnea-hypopnea index that could cause a pathological CDI score (?19) was >5.66, and the cutoff point for the oxygen desaturation index was >4.2. The limitations of this study are that our data are derived from one single psychometric test and not from a complete psychiatric evaluation, and our subjects came from a small group in southern Italy.Our results suggest the importance of mood assessment in children affected by SRBD.
HubMed – depression
ARELIA – Heart Chakra healing * binaural depression treatment – 4th Chakra healing and balancing meditation, binaural depression treatment ARELIA – Track (Angel heart) Album – (Infinite Sounds)
Amoryn – Depression & AnxietyAMORYN works by increasing the levels of all four of the brain’s “feel good” neurotransmitters. By providing an all-natural boost …
Treatment Plans and Interventions for Depression and Anxiety DisordersIncludes CD-ROM with Reproducible Forms!This one-of-a-kind resource provides the busy practitioner with empirically supported trea…
Fighting and Winning Over Depression: My Practical Thoughts and Spiritual Journey5 Star Reviews:”This book speaks directly to those dealing with depression and those who wish to understand depression better. A v…
Find More Depression Treatment Information…