Depression Treatment: Depression in Japanese Patients With Chronic Obstructive Pulmonary Disease. a Cross-Sectional Study.
Depression in Japanese Patients with Chronic Obstructive Pulmonary Disease. A Cross-Sectional Study.
Filed under: Depression Treatment
Respir Care. 2012 Dec 4;
Horita N, Kaneko T, Shinkai M, Yomota M, Morita S, Rubin BK, Ishigatsubo Y
BACKGROUND: Some investigation revealed the association between depression and physical measurements of chronic obstructive pulmonary disease (COPD) patients in North America and Europe but limited studies in Asia were performed. METHODS: In this cross-sectional study, consecutive 84 stable outpatients with COPD (Age: 72.0 ± 9.0. Forced expiratory volume in one second (%predicted) 46 ± 15%. Fifteen females (17.9%)) in a Japanese community based hospital were recruited. “Probable depression” was defined as short form of the geriatric depression scale (SF-GDS) ? 6. Relationships among commonly used physical measurements, SF-GDS raw score, and probable depression were evaluated with Spearman’s rank correlation test, multiple linear regression analysis, logistic regression analysis, and receiver operating characteristic curve. RESULTS: Thirty two (38.1%) had probable depression. Body mass index, obstruction, dyspnea, exercise capacity index; forced expiratory volume in one second (%predicted); modified medical research council dyspnea scale; six-minute walk distance; saturation of oxygen on artery by pulse oximetry had followings: (i) simple correlations (|r|:0.42 0.60 , P < .001 for all) for SF GDS raw score, (ii) partial correlations (|r|:0.25 0.51 , P < .05 for all) for SF GDS raw score after adjusting demographic and social factors, (iii) association for probable depression in logistic regression analysis after adjusting demographic and social factors (P < .05 for all), and (iv) area under the receiver operating characteristic curves for probable depression (area under the curves: 0.719-0.841, P < .001 for any), CONCLUSIONS: Physical parameters were associated with depression in our Japanese COPD outpatients. HubMed – depression
Depression and aggression in never-married men in China: a growing problem.
Filed under: Depression Treatment
Soc Psychiatry Psychiatr Epidemiol. 2012 Dec 12;
Zhou X, Yan Z, Therese H
PURPOSE: China has the highest excess of male births in the world at 118 to every 100 female, with a current excess of 20 million men of reproductive age. The impact on the psychological well-being of the large numbers of men who will never marry is unclear. This study was carried out to test the hypothesis that older never-married men are more predisposed to depression, low self-esteem and aggression. METHODS: The study was a cross-sectional survey using a self-completion questionnaire conducted in high sex ratio rural areas of Yunnan and Guizhou provinces. The tools used were the Beck Depression Inventory, Rosenberg’s Self-Esteem Scale and the Bryant-Smith Aggression questionnaire. RESULTS: A total of 1,059 never-married men and 1,066 married men aged 30-40 completed questionnaires. Never-married men were financially poorer and had lower education levels than married ones. After adjusting for age, education and income, never-married men were significantly more likely to have lower self-esteem scores (P < 0.001), higher depression scores (P < 0.001), higher aggression scores (P < 0.001) and were more likely to have suicidal thoughts or wishes (P < 0.001) than married men. CONCLUSION: The high prevalence of severe depression and suicide ideation in these men is of particular concern. In rural China mental health services are currently very sparse, but rural doctors could be trained to use a check score to identify severe depression, and refer as appropriate to specialist services. HubMed – depression
Sertraline exposure leads to small left heart syndrome in adult mice.
Filed under: Depression Treatment
Pediatr Res. 2012 Dec 11;
Haskell SE, Hermann GM, Reinking BE, Volk KA, Peotta VA, Zhu V, Roghair RD
Background:Sertraline, a selective serotonin reuptake inhibitor (SSRI), is the most commonly prescribed therapy for maternal depression. Epidemiologic studies have linked SSRI exposure with decreased fetal growth, altered autonomic regulation, and cardiac malformations. We hypothesized SSRI exposure decreases left ventricular volumes and increases adult sympathetic nervous system activation, resulting in increased adult heart rates.Methods:C57BL/6 mice received saline or sertraline (5 or 15?mg/kg/day i.p.) on postnatal days 1-14. Adult phenotypes were assessed at 5 months.Results:Sertraline-exposed mice had smaller left ventricular internal diameters in diastole (control 4.0 + 0.1?mm, SSRI 3.7 + 0.1?mm, p < 0.05), decreased stroke volumes (control 46 + 2.6 µL, SSRI 37 + 2.3 µL, p < 0.05), higher heart rates (control 530 + 13 beats per minute (bpm), SSRI 567 + 6 bpm, p <0.05) and increased urinary excretion of noradrenaline (control 174 + 29.4?ng/mL, SSRI 276 + 35.1?ng/mL, p<0.05). These changes were associated with increased cerebral serotonin transporter (5-HTT) expression.Conclusion:Neonatal sertraline exposure causes long term changes in cardiac morphology and physiology. We speculate that early life SSRI exposure impairs cardiomyocyte growth and central serotonin signaling, leading to a small left heart syndrome in adult mice.Pediatric Research (2012); doi:10.1038/pr.2012.183. HubMed – depression
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