Depression Treatment: Refractory Major Depression Successfully Treated With Electroconvulsive Therapy in a Patient With Addison Disease.

Refractory Major Depression Successfully Treated With Electroconvulsive Therapy in a Patient With Addison Disease.

Filed under: Depression Treatment

J ECT. 2013 Jan 9;
Heijnen WT, Pluijms EM, Birkenhager TK

ABSTRACT: This report describes a 55-year-old woman who had 1 previous episode of major depression that responded favorably to treatment with tricyclic antidepressants. After the development of Addison disease, she experienced a new episode of major depression that failed to respond to adequate treatment with imipramine and was subsequently successfully treated with electroconvulsive therapy (ECT) with steroid cover. The patient did not experience adrenal crisis or adverse effects. After 9 ECT sessions, she attained full remission. These findings support the suggestion that ECT treatment is safe in patients with Addison disease when using 100 mg intravenous hydrocortisone as prophylaxis.
HubMed – depression

Effect of Propofol Versus Sodium Thiopental on Electroconvulsive Therapy in Major Depressive Disorder: A Randomized Double-Blind Controlled Clinical Trial.

Filed under: Depression Treatment

J ECT. 2013 Jan 31;
Purtuloglu T, Ozdemir B, Erdem M, Deniz S, Balkç A, Unlü G, Oznur T

OBJECTIVES: To compare propofol and sodium thiopental as anesthetic agents for electroconvulsive therapy (ECT) in major depression with respect to clinical effect. METHODS: Participants were composed of 96 patients with depression who were administered either propofol or sodium thiopental as an anesthetic agent for bilateral ECT. The Hamilton Depression Rating Scale was administered at baseline and after 6 treatments. Algorithm-based charge dosing was used. RESULTS: There was a statistically significant difference between the groups regarding postintervention Hamilton Depression Rating Scale score. The preintervention mean (SD) scores in the propofol group and the sodium thiopental group were 37.3 (2.2) and 36.7 (1.2), respectively. The postintervention mean (SD) scores in the propofol group and the sodium thiopental group were 10.7 (1.8) and 13.4 (3.3), respectively. No correlation was found between clinical response and age, weight, and body mass index. There was no association between the groups’ seizure time and duration of recovery. CONCLUSIONS: In conclusion, propofol may improve major depressive disorder more than sodium thiopental in patients who are receiving ECT.
HubMed – depression

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