Drug and Alcohol Rehabilitation: The Use of Clobazam as an Adjunctive Treatment for Lennox-Gastaut Syndrome.
The use of clobazam as an adjunctive treatment for Lennox-Gastaut syndrome.
Filed under: Drug and Alcohol Rehabilitation
Drugs Today (Barc). 2012 Nov; 48(11): 697-703
Owen RT
Clobazam, a 1,5-benzodiazepine, has been available in many European countries since the 1970s, both as an anxiolytic and as an antiepileptic. Recently, it has been marketed in the U.S. for the adjunctive treatment of Lennox-Gastaut syndrome, a seizure disorder accompanied by mental retardation and/or learning difficulties. The condition is usually refractory to many antiepileptic agents. The pivotal phase II and III trials of adjunctive clobazam are reviewed together with its postulated mode of action, pharmacokinetics and drug interaction profile. The data are discussed in terms of existing FDA-approved agents for Lennox-Gastaut syndrome and suggestions for further work.
HubMed – drug
[Delusional disorder: clinical picture and treatment].
Filed under: Drug and Alcohol Rehabilitation
Vertex. 2012 Jul-Aug; 23(104): 255-9
Elenitza IM
In 1987, the revision of the DSM-III reintroduced the concept of paranoia under the name of delusional disorder. Most of the actual evidence about the pharmacological treatment of this disorder is derived from case series and case reports. Antipsychotics have been used for the treatment of delusional disorder since 1970s, with pimozide as a first line drug. The introduction of second generation antipsychotics changed the treatment of the disorder. In spite of the available information, delusional disorder remains to this day a controversial and complex disorder.
HubMed – drug
[Thalidomide and its legacy, the rational inside the irrational].
Filed under: Drug and Alcohol Rehabilitation
Vertex. 2012 Jul-Aug; 23(104): 245-51
Fadel DO, Serra HA
Thalidomide was synthesized by Chemie Grünenthal from Germany and launched at October 1957, as a sedative and antiemetic drug. In only four years after being widely and freely prescribed to pregnant women, unleashed an epidemic of teratogenicity that revolutionized health and public opinion. From that moment, world regulation on drugs and its development was radically changed, the clinical trial as a tool was completely revised, while pharmacovigilance as a discipline was established. In a second chance, its irrational use as psychotropic drug was changed to use as immunomodulator, context in which it is prescribed today. This paper aims to highlight some historical aspects of thalidomide to draw conclusions for rational use of psychotropic drugs.
HubMed – drug
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