Electroacupuncture Exerts Anti-Inflammatory Effects in Cerebral Ischemia-Reperfusion Injured Rats via Suppression of the TLR4/NF-?B Pathway.

Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-?B pathway.

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Int J Mol Med. 2012 Nov 16;
Lan L, Tao J, Chen A, Xie G, Huang J, Lin J, Peng J, Chen L

Inflammatory response has been shown to play a critical role in brain damage after cerebral ischemia-reperfusion (I/R) injury, which is tightly regulated by the Toll-like receptor (TLR)4/nuclear factor (NF)-?B pathway; therefore, suppression of TLR4/NF-?B signaling has become a promising target for the anti-inflammatory treatment in ischemic stroke. Acupuncture has been used as a complementary and alternative therapy practice that supplements conventional medicine. Numerous studies have demonstrated the clinical efficacy of acupuncture in stroke rehabilitation. However, the precise mechanism of its neuroprotective effect remains poorly understood. Using a focal cerebral I/R injured rat model, in the present study we evaluated the neuroprotective and anti-inflammatory activities of electroacupuncture at Quchi and Zusanli, and investigated the underlying molecular mechanisms. We found that electroacupuncture at Quchi (LI11) and Zusanli (ST36) acupoints significantly improved the ischemia-associated scores of neurological deficits, reduced cerebral infarction and alleviated inflammatory responses. Moreover, the crucial signaling molecules in the TLR4/NF-?B signaling pathway were regulated by acupuncture, which coincided with suppressed secretion levels of inflammatory cytokines such as TNF-?, IL-1? and IL-6. Our data suggest that electroacupuncture exerts a neuroprotective function in ischemic stroke through inhibition of TLR4/NF-?B-mediated inflammation.
HubMed – rehab

[Overcrowding in prisons and its impact on health].

Filed under: Rehab Centers

Rev Esp Sanid Penit. 2012 Feb; 14(3): 106-13
García-Guerrero J, Marco A

Overcrowding in prisons is a common problem that affects many countries. It is difficult to define this term because there is no single internationally accepted standard. However, this is a situation that must be counteracted, because people’s behaviour can be affected to the extent that it leads to self-harm or violent behaviour to others. But prison overcrowding also has other effects on the health and well being of the people living in these conditions and may also adversely affect public health and the prison system. It can increase the prevalence of diseases, particularly infectious and psychiatric disorders. It may also hinder the work of social rehabilitation and lead to inhuman, cruel or degrading treatment. This paper reviews the scant literature about overcrowding in prisons. Increasing awareness about the issue in the international community and prison administrations and above all, assigning specific economic resources, are key elements in preventing this deficit in social welfare and health care.
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Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Filed under: Rehab Centers

Spinal Cord. 2012 Nov 20;
Facchinetti LD, Araújo AQ, Chequer GL, de Azevedo MF, de Oliveira RV, Lima MA

Study design:Cross-sectional study.Objectives:To determine the prevalence of falls in human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients and possible factors associated to their occurrence.Setting:Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz (FIOCRUZ) – Brazil.Methods:Thirty-six HAM/TSP patients able to walk at least 20?m were assessed by a questionnaire. Data regarding gender, age, duration of disease (DD), HTLV-I proviral load (HPL), frequency of physical activity (FCA), use of walking aids, functional ambulation level, the number of falls and associated injuries in the last year were reviewed. Multiple correspondence analysis was used to group characteristics of this sample according to the fall occurrence.Results:The prevalence of falls was 63.9% and we observed injuries in 47.8% of the cases. Four groups were identified in the descriptive analysis. One group was formed by faller individuals, men <60 years, independent ambulation, FCA?3 times per week and HPL <6.6 copies per 100 cells (group B). The other one comprised non-faller patients, women ?60 years, restricted ambulation, DD ?7 years, use of orthosis, FCA 0-1 time per week and HPL ?6.6 copies per 100 cells (group D). The others two groups comprised individuals that did not use orthosis (group A) and those that FCA was two times per week and DD <7 years (group C).Conclusion:Falls occur in roughly two-thirds of ambulatory HAM/TSP patients and are associated with significant morbidity. Further studies with a larger number of patients are necessarily to identify risk factors in order to elaborate specific programs to prevent falls in this population.Spinal Cord advance online publication, 20 November 2012; doi:10.1038/sc.2012.134. HubMed – rehab

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