Good Medium-Term Efficacy of Tocilizumab in DMARD and Anti-TNF-? Therapy Resistant Reactive Amyloidosis.
Good medium-term efficacy of tocilizumab in DMARD and anti-TNF-? therapy resistant reactive amyloidosis.
Filed under: Rehab Centers
Ann Rheum Dis. 2012 Nov 12;
Hakala M, Immonen K, Korpela M, Vasala M, Kauppi MJ
Molecular changes in detrained & retrained adult jaw muscle.
Filed under: Rehab Centers
Eur J Orthod. 2012 Nov 11;
Odman AM, Hunt NP, Matloub Moawad HA, Sinanan AC, Kiliaridis S, Lewis MP
SUMMARYA hypofunctional masticatory system was developed in 21-day-old male rats by feeding them a soft diet for 27 weeks. Retraining of a parallel group for 6 weeks was achieved by switching back to a hard diet after 21 weeks. A control group was fed a hard diet for 27 weeks. At the end of the experimental period, the expression levels of the myosin heavy chain isoform genes MYH 1 and 2 (fast), 3 (embryonic) and 7 (slow) in the deep masseter were compared using qRT-PCR analysis.The gene expressions of MYH 3 and MYH 7 were significantly higher in the rehabilitation group compared with the normal and hypofunctional group, but no significant differences were found in regards to the gene expression of MYH 1 and 2.Retraining made it possible for the slow (MYH 7) isoform levels to adapt to the increased mechanical load. The increased level of embryonic (MYH 3) isoform could be due to the need of creation of new MYH isoforms.
HubMed – rehab
Occupational Experiences and Subjective Well-being of Mothers of Children with ASD in Taiwan.
Filed under: Rehab Centers
Occup Ther Int. 2012 Nov 13;
Hsieh YL, Lo JL
This study investigated the relationship between mothers’ daily occupational experiences of productivity, restoration and pleasure with their subjective well-being (SWB) and with their child’s developmental skills. Forty caregivers parenting young children with autism spectrum disorders served as a convenience sample in this study. Participants rated their occupational experience in a time diary for a 1-week period and rated their SWB on the Positive and Negative Affect Scale and Satisfaction with Life Scale. Their child’s occupational performance and development were evaluated using the Pediatric Daily Occupation Scale and Chinese Child Development Inventory. Spearman rank correlations were used to examine the relationship of SWB to these maternal and child factors. Mothers’ pleasure levels were associated with two SWB measures: the positive affect and Satisfaction With Life Scale. Restoration levels related to positive affect only. Productivity levels and child factors were not significantly correlated with any of the SWB measures. A larger heterogeneous sample and a longitudinal study design to explore the fluctuation and stability of occupational experiences across time are recommended to examine caregivers’ adaptation and/or alterations in SWB while adapting to their child’s diagnosis and special needs. Copyright © 2012 John Wiley & Sons, Ltd.
HubMed – rehab
Neuromuscular Stimulation of Quadriceps in Patients Hospitalised during an Exacerbation of COPD: A Comparison of Low (35?Hz) and High (50?Hz) Frequencies.
Filed under: Rehab Centers
Physiother Res Int. 2012 Nov 13;
Chaplin EJ, Houchen L, Greening NJ, Harvey-Dunstan T, Morgan MD, Steiner MC, Singh SJ
BACKGROUND: Neuromuscular electrical stimulation (NMES) has shown to improve skeletal muscle strength and exercise capacity in stable patients with chronic obstructive pulmonary disease (COPD). Variations in NMES protocols are considerable. We aimed to compare changes in muscle strength after high-frequency and low-frequency NMES in patients admitted to hospital with an acute exacerbation of COPD. METHODS: Patients were referred for inpatient (IP) rehabilitation during hospitalisation for an acute worsening of their COPD. They received 30-minute daily NMES to both quadriceps at a frequency of 35 or 50?Hz. NMES intensity was titrated to patients’ tolerance. Isometric quadriceps muscle strength and endurance walking (ESWT) time were measured at baseline and on hospital discharge. RESULTS: A total of 10 patients in each treatment group underwent NMES during hospitalisation (mean [SD] age 68.0 [±7.4] years, FEV1 0.99?L [±0.58], FEV1/FVC 47% [± 27%], MRC 5 [IQR ±1]). There were no significant differences in baseline characteristics between groups. Muscle strength (legs combined) increased in both groups regardless of the NMES frequency used (35?Hz – 3.8?±?4.9; 50?Hz – 3.4?±?5.5?kg). This was only significant within the 35?Hz group. The change in ESWT also showed a trend to increase in both groups (35?Hz – 109?±?92.7; 50?Hz – 145.6?±?94.7). There was no significant difference between groups for either outcome. CONCLUSION: NMES is a feasible intervention to improve muscle strength in a cohort of patients admitted with an exacerbation of COPD. The response appears to be independent of the frequency used and both were well-tolerated. Copyright © 2012 John Wiley & Sons, Ltd.
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