Rehab Centers: Chronic Exercise Training Down-Regulates TNF-? and Atrogin-1/MAFbx in Mouse Gastrocnemius Muscle Atrophy Induced by Hindlimb Unloading.
Chronic Exercise Training Down-Regulates TNF-? and Atrogin-1/MAFbx in Mouse Gastrocnemius Muscle Atrophy Induced by Hindlimb Unloading.
Filed under: Rehab Centers
Acta Histochem Cytochem. 2012 Dec 26; 45(6): 343-9
Al-Nassan S, Fujita N, Kondo H, Murakami S, Fujino H
The purpose of this study was to investigate the effect of chronic moderate-intensity training in order to prevent muscle atrophy with a focus on TNF-? and atrogin-1/MAFbx as main proteolytic indicators. Hindlimb unloading model of mice received treadmill running exercise for 1 hr per day during hindlimb unloading period of 6 weeks. The gastrocnemius muscle mass, muscle fiber cross-sectional area, and succinate dehydrogenase (SDH) activity in the muscle fiber were higher in the exercised group, while TNF-? and atrogin-1/MAFbx mRNA expressions were significantly lower. Results in the present study showed that chronic exercise could prevent over expression of TNF-? and atrogin-1/MAFbx in the atrophied skeletal muscle, providing further support to the effects of chronic exercise training on muscle atrophy.
HubMed – rehab
Translating research into clinical practice: the role of quality improvement in providing rehabilitation for people with critical illness.
Filed under: Rehab Centers
Phys Ther. 2013 Feb; 93(2): 128-33
Ohtake PJ, Strasser DC, Needham DM
Boston keratoprosthesis for visual rehabilitation in porphyria cutanea tarda.
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BMJ Case Rep. 2013; 2013:
Sati A, Sangwan VS, Basu S, Kalaiselvan P
A 56-year-old man, presented with bilateral chronic visual loss associated with generalised skin lesions. He had undergone multiple penetrating keratoplasties in his right eye for recurrent corneal infections and perforations. On ocular examination, his left eye was phthisical and his right eye had light perception vision owing to a failed and vascularised corneal graft. Dermatological evaluation revealed multiple hyperpigmented and hypopigmented lesions along with thickening of skin on nose, scalp and dorsum of hands. Skin biopsy showed focal areas of deposition of faint periodic acid Schiff-positive diastase-resistant perivascular material. The high-performance liquid chromatography assessment revealed increased presence of porphyrins in blood and urine, thus confirming a diagnosis of porphyria cutanea tarda. The patient’s vision in the right eye improved after undergoing Boston type 1 keratoprosthesis along with general photoprotective measures for the exposed parts of the body.
HubMed – rehab
Locked-in syndrome.
Filed under: Rehab Centers
Tex Med. 2013; 109(2): e1
Cardwell MS
Locked-in syndrome is a rare neuropsychological disorder. Its primary features are quadriplegia and paralysis of the cranial nerves except for those responsible for vertical eye movements. The differential diagnosis includes persistent vegetative state, brain death, minimally conscious states, C3 transection of the spinal cord, and conversion locked-in syndrome. Etiologies of locked-in syndrome include hemorrhagic and thrombotic events, tumors affecting the ventral pons, infectious agents, iatrogenic causes, trauma, metabolic abnormalities, and other miscellaneous causes. The clinical manifestations, differential diagnosis, neuropsychological assessment, rehabilitation, and prognosis of patients with locked-in syndrome are discussed.
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