Rehab Centers: The Trend of Hospital Accreditation in the Kingdom of Saudi Arabia.

The trend of hospital accreditation in the Kingdom of Saudi Arabia.

Filed under: Rehab Centers

Saudi Med J. 2012 Dec; 33(12): 1350-1
Qureshi AZ, Ullah S, Ullah R

HubMed – rehab

The Na(V)1.7 sodium channel: from molecule to man.

Filed under: Rehab Centers

Nat Rev Neurosci. 2012 Dec 12;
Dib-Hajj SD, Yang Y, Black JA, Waxman SG

The voltage-gated sodium channel Na(V)1.7 is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons. Na(V)1.7 accumulates at nerve fibre endings and amplifies small subthreshold depolarizations, poising it to act as a threshold channel that regulates excitability. Genetic and functional studies have added to the evidence that Na(V)1.7 is a major contributor to pain signalling in humans, and homology modelling based on crystal structures of ion channels suggests an atomic-level structural basis for the altered gating of mutant Na(V)1.7 that causes pain.
HubMed – rehab

Quality of Life Before Intensive Care Using EQ-5D: Patient Versus Proxy Responses.

Filed under: Rehab Centers

Crit Care Med. 2012 Dec 10;
Dinglas VD, Gifford JM, Husain N, Colantuoni E, Needham DM

OBJECTIVE:: To compare patients’ retrospectively reported baseline quality of life before intensive care hospitalization with population norms and proxy reports. DESIGN:: Prospective cohort study. SETTING:: Thirteen ICUs at four teaching hospitals in Baltimore, MD. PATIENTS:: One hundred forty acute lung injury survivors and their designated proxies. INTERVENTIONS:: Around the time of hospital discharge, both patients and proxies were asked to retrospectively estimate patients’ baseline quality of life before hospital admission using the EQ-5D quality-of-life instrument. MEASUREMENTS AND MAIN RESULTS:: Mean patient-rated EQ-5D visual analog scale scores and utility scores were significantly lower than population norms but were significantly higher than proxy ratings. However, the magnitude of difference in average utility scores between patients and either population norms or proxies was not clinically important. For the five individual EQ-5D domains, ? statistics revealed slight to fair agreement between patients and proxies. Bland-Altman plots demonstrated that for both the visual analog scale and utility scores, proxies underestimated scores when patients reported high ratings and overestimated scores for low patient ratings. CONCLUSIONS:: Patients retrospectively reported worse baseline health status before acute lung injury than population norms and better status than proxy reports; however, the magnitude of these differences in health status may not be clinically important. Proxies had only slight to fair agreement with patients in all five EQ-5D domains, attenuating patients’ more extreme ratings toward moderate scores. Caution is required when interpreting proxy retrospective reports of baseline health status for survivors of acute lung injury.
HubMed – rehab

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