Repurposing Buspirone for Drug Addiction Treatment.
Repurposing buspirone for drug addiction treatment.
Filed under: Addiction Rehab
Int J Neuropsychopharmacol. 2012 Oct 19; 1-3
Le Foll B, Boileau I
Striatocortical pathway dysfunction in addiction and obesity: differences and similarities.
Filed under: Addiction Rehab
Crit Rev Biochem Mol Biol. 2012 Nov 23;
Tomasi D, Volkow ND
Neuroimaging techniques are starting to reveal significant overlap in the brain circuitry underlying addiction and disorders of dyscontrol over rewarding behaviors (such as binge eating disorder and obesity). Positron emission tomography (PET) has demonstrated impaired striatal dopamine (DA) signaling (decreased D2 receptors) in drug addiction and obesity that is associated with reduced baseline glucose metabolism in medial and ventral prefrontal brain regions. Functional magnetic resonance imaging (fMRI) has documented brain activation abnormalities that also implicate DA-modulated striato-cortical pathways. In this review we map findings from recent neuroimaging studies that differentiate brain activation in drug/food addiction from those in controls within brain networks functionally connected with ventral and dorsal striatum. We show that regions found to be abnormal in addiction and obesity frequently emerge at the overlap of the dorsal and the ventral striatal networks. Medial temporal and superior frontal regions functionally connected with dorsal striatum display greater vulnerability in obesity and eating disorders than in drug addictions, indicating more widespread abnormalities for obesity and eating disorders than for addictions. This corroborates involvement of both ventral striatal (predominantly associated with reward and motivation) and dorsal striatal networks (associated with habits or stimulus response learning) in addiction and obesity but also identify distinct patterns between these two disorders.
HubMed – addiction
Are we near a limit or can we get more safety from vehicle alcohol interlocks?
Filed under: Addiction Rehab
Addiction. 2012 Nov 22;
Marques P, Voas R
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