Reviewers for Clinical Rehabilitation July 2011 to June 2012.
Reviewers for Clinical Rehabilitation July 2011 to June 2012.
Filed under: Rehab Centers
Clin Rehabil. 2012 Dec; 26(12): 1150-1151
Radiologic differences in white matter maturation between preterm and full-term infants: TBSS study.
Filed under: Rehab Centers
Pediatr Radiol. 2012 Nov 13;
Lee AY, Jang SH, Lee E, Ahn SH, Cho HK, Jo HM, Son SM
BACKGROUND: Widespread white matter (WM) pathology in preterm children has been proposed. OBJECTIVE: The purpose of this study was to investigate maturational differences of WM between preterm infants with thinning of the corpus callosum and full-term infants. MATERIALS AND METHODS: A total of 18 preterm children and 18 full-term children were divided into three subgroups according to the corrected age at the time of diffusion tensor imaging scanning. Tract-based spatial statistics was used for assessing differences in fractional anisotropy (FA) between preterm and full-term children, and between each age-related subgroup in preterm and in full-term children. RESULTS: In the preterm group, FA values of overall WM showed an increase with age. This trend indicates that WM maturation is a gradual occurrence during a child’s first 2 years. In the full-term group, most WM structures had reached maturation at around 1 year of age; however, centrum semiovale level showed sustained maturation during the first 2 years. CONCLUSION: Results of our study demonstrate radiologic maturational differences of WM and provide evidence of the need for therapeutic intervention within 2 years of birth to prevent specific functional impairment and to improve clinical outcome in preterm children.
HubMed – rehab
Autoantibodies are not associated with familial mediterranean fever.
Filed under: Rehab Centers
Acta Reumatol Port. 2012 Apr; 37(2): 144-148
Guler E, Kaptanoglu E, Sahin O, Candan F, Hayta E, Elden H
Objective: It has been suggested that Mediterranean fever (MEFV) gene mutations are also seen in certain autoimmune diseases and are related to severity of the disease activity. As most of the clinical symptoms of these inflammatory diseases are related to autoantibody positivity, we assessed autoantibody prevalence in patients with Familial Mediterranean fever (FMF) and investigated the relationship between clinical involvement of FMF and the autoantibodies. There are a few studies on this subject with conflicting results. Patients and Methods: Fifty patients with FMF without attack and 27 healthy controls were enrolled to the study. Clinical characteristics of the patient group were questioned. Rheumatoid factor (RF), anti-cyclic citrulliated peptide (anti-CCP) values, Fluorescent antinuclear antibody (ANA), extractable nuclear antigen (ENA) profile was studied in both groups. Results: No statistically significant difference was found in ANA, ENA profile, anti-CCP, and RF positiviy between the groups (p>0.05). There was no relationhip between the autoantibodies and the clinical status in patients with FMF. MEFV gene mutations were identified in 98% of the FMF patients. Conclusion: In conclusion, autoantibody positivity is similar to the healthy population in FMF. Although MEFV mutations affect clinical course in other autoantibody mediated diseases, it is not related to autoantibody formation in FMF.
HubMed – rehab
Finding Rheumatoid Arthritis Impact on Life (FRAIL Study): economic burden.
Filed under: Rehab Centers
Acta Reumatol Port. 2012 Apr; 37(2): 134-142
Miranda LC, Santos H, Ferreira J, Coelho P, Silva C, Saraiva-Ribeiro J
Introduction: The economic impact of rheumatoid arthritis (RA) is related with the costs supported by the society. It is of the utmost importance to estimate the costs of RA in Portugal in order to access its true social impact and improve the clinical management of this disease. Objectives: To determine the yearly direct and indirect costs of RA supported by the society in Portugal. Methods: Observational, cross-sectional study with collection of retrospective data, involving patients with RA, diagnosed accordingly to 1987 American College of Rheumatology (ACR) criteria, independently of diease stage, with attendance to a specialist visit between October and December 2009 in a Rheumatology Clinic in Portugal. Data were obtained through the fulfillment of medical and patient questionnaires. Data being coveed included socio-demographic and clinical characteistics and health resources. The societal perspective was considered including direct and indirect costs. Unitary costs were obtained from official national sources. Results: The FRAIL study included 353 patients, 84% females, with an average age of 59 (range: 23-85 years). In the previous year: 97.2% of patients had a Rheumatology appointment (average: 4) and 35.6% a GP appointments (average: 6); 8.2% were hospitalized at least once, 9.3% had an urgency admission and 41.4% went to the day hospital. Most of the patients (96.0%) were on DMARD; 94.3% performed routine exams; 35.7% had rehabilitation treatments; 21.4% had alternative medicine treatments; 5.7% needed house adaptations; 9.3% needed prosthesis; 5.1% needed permanent home support, 2.9% partial; 31% of the patients referred sick leave because of RA. We estimate that the annual mean cost of treating one RA patient in Portugal is about 3.415, of which 77.3%, 9.6% and 11.4%, corresponds to direct medical, direct non-medical and indirect cost, respectively. Total cost of the disease increase with disease activity. RA in remission has an average cost of 2.205/patient/year versus 5.634 in high activity RA. Conclusions: Results of the FRAIL study allow a better understanding of the real economic impact of RA for society, which increased very significantly in the last 10 years. If we consider 35 000 patients with RA in Portugal, the annual cost would be 119 525 000 per year.
HubMed – rehab
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