Self-Inflicted Male Bladder Foreign Body: Its Endoscopic Removal Using a Rigid Cystoscope and a Suprapubic Forceps.

Self-inflicted male bladder foreign body: its endoscopic removal using a rigid cystoscope and a suprapubic forceps.

Case Rep Urol. 2013; 2013: 729013
Moslemi MK, Sorani M

Introduction. Herein we present an interesting technique for the removal of bladder foreign body (BFB) in which a combination of endoscopic and suprapubic cystostomy was used. Case Presentation. The patient was a case of illicit drug abuser who self-introduced an electrical wire into his bladder. After its failed cystoscopic removal, the foreign body was removed suprapubically without open bladder surgery. Discussions. Bladder foreign bodies are not uncommon. Based on the literature review, mainly open surgeries were used for their treatment. Using of our less invasive technique is a good way for escaping from open cystostomy. Conclusion. Endoscopic removal of the bladder foreign bodies is possible without any need for open bladder surgery. HubMed – drug

In Silico Prediction of Interactions between Site II on Human Serum Albumin and Profen Drugs.

ISRN Pharm. 2013; 2013: 818364
Isogai H, Hirayama N

Since binding of a drug molecule to human serum albumin (HSA) significantly affects the pharmacokinetics of the drug, it is highly desirable to predict the binding affinity of the drug. Profen drugs are a widely used class of nonsteroidal anti-inflammatory drugs and it has been reported that several members of the profen class specifically bind to one of the main binding sites named site II. The actual binding mode of only ibuprofen has been directly confirmed by X-ray crystallography. Therefore, it is of interest whether other profen drugs are site II binders. Docking simulations using multiple template structures of HSA from three crystal structures of complexes between drugs and HSA have demonstrated that most of the currently available profen drugs should be site II binders. HubMed – drug

Gd(3+)-DTPA-Meglumine-Anionic Linear Globular Dendrimer G1: Novel Nanosized Low Toxic Tumor Molecular MR Imaging Agent.

ISRN Pharm. 2013; 2013: 378452
Darvish Mohamadi T, Amanlou M, Ghalandarlaki N, Mehravi B, Shafiee Ardestani M, Yaghmaei P

Despite the great efforts in the areas of early diagnosis and treatment of cancer, this disease continues to grow and is still a global killer. Cancer treatment efficiency is relatively high in the early stages of the disease. Therefore, early diagnosis is a key factor in cancer treatment. Among the various diagnostic methods, molecular imaging is one of the fastest and safest ones. Because of its unique characteristics, magnetic resonance imaging has a special position in most researches. To increase the contrast of MR images, many pharmaceuticals have been known and used so far. Gadopentetate (with commercial name Magnevist) is the first magnetic resonance imaging contrast media that has been approved by the US Food and Drug Administration. In this study, gadopentetate was first synthesized and then attached to a tree-like polymer called dendrimer which is formed by polyethylene glycol core and surrounding citric acid groups. Stability studies of the drug were carried out to ensure proper synthesis. Then, the uptake of the drug into liver hepatocellular cell line and the drug cytotoxicity were evaluated. Finally, in vitro and in vivo MR imaging were performed with the new synthetic drug. Based on the findings of this research, connecting gadopentetate to dendrimer surface produces a stronger, safer, and more efficient contrast media. Gd(III)-diethylenetriamine pentaacetate-meglumine-dendrimer drug has the ability to enter cells and does not produce significant cytotoxicity. It also increases the relaxivity of tissue and enhances the MR images contrast. The obtained results confirm the hypothesis that the binding of gadopentetate to citric acid dendrimer produces a new, biodegradable, stable, and strong version of the old contrast media. HubMed – drug

Characteristics and outcomes of cocaine-related spontaneous intracerebral hemorrhages.

ISRN Neurol. 2013; 2013: 124390
Bajwa AA, Silliman S, Cury JD, Seeram V, Shujaat A, Usman F, Samuel V

To date there is only one single-center study that has exclusively reported characteristics, location, and outcomes of spontaneous intracerebral hemorrhages (ICH) among cocaine users. We aimed to describe the radiological location and characteristics along with clinical outcomes of spontaneous ICH in a similar population. We conducted a retrospective chart review of consecutive patients admitted to a tertiary care hospital, with a spontaneous ICH, who had a urine drug screen performed within 48 hours of admission. Exposure to cocaine was defined by a positive urine drug screen within 48 hours of hospital admission. Demographics, radiographic features of ICH, and short-term clinical outcomes of patients with a positive urine drug screen were analyzed and compared with the cocaine negative group. Among the 102 patients analyzed, 20 (19.6%) had documented exposure to cocaine. There was a predominance of males in both groups with significantly more Blacks in the cocaine positive group (P = 0.0246). A statistically significant number of patients with cocaine use had ICH in a subcortical location (P = 0.0224) when compared to cocaine negative patients. There was no difference in GCS, ICH volume, intraventricular extension, ICU days, hospital days, hospital cost, mortality, and ICH score. ICH in cocaine use is more frequently seen in the subcortical location. HubMed – drug

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